MOTS-c 10mg

MOTS-c 10mg

$104.00

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino acid peptide encoded by the mitochondrial 12S rRNA gene, first discovered in 2015. As a key mitochondrial-derived peptide, MOTS-c plays a vital role in regulating metabolism, stress responses, and processes related to aging. What sets MOTS-c apart is its ability to translocate to the nucleus under metabolic stress, where it influences nuclear gene expression to support cellular adaptation and maintain homeostasis, making it a promising target for therapeutic research.

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Referenced Citations

  1. Lee, C., et al. (2015). “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metabolism, 21(3), 443-454.
  2. Kim, K.H., et al. (2018). “The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress.” Cell Metabolism, 28(3), 516-524.e7.
  3. Reynolds, J.C., et al. (2021). “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nature Communications, 12(1), 470.
  4. Zheng, Y., et al. (2023). “MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.” Frontiers in Physiology, 14, 1149120.
  5. Liu, Z., et al. (2023). “MOTS-c functionally prevents metabolic disorders.” Nutrients, 15(2), 300.

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